‘Indeed, that is about appropriate. I search for a Bodily comprehension of biological techniques in a very bottom-up way. I believe you could possibly distinguish three lines of exploration in my team in the intervening time. The very first problems chromosome structure: How would you have a metre-long DNA polymer folded and organised in this type of microscopic cell? We have now developed visualisation strategies that make it possible for us to check how, for instance, SMC proteins loop DNA (video clip on Youtube) so as to Establish up chromosomes.

1996, first mesoscopic cost density waves equipment; and initial electrical measurements on one metallic nanocluster among nanoelectrodes

Multicolor imaging in the bacterial nucleoid and cell division proteins with blue, orange, and in the vicinity of-infrared fluorescent proteins

Sculpting nano-electrodes using a transmission electron beam for electrical and geometrical characterization of nanoparticles.

That may be a dream of mine and we set to operate having a mouth watering dose of naivety. This can be a thing that will probably produce amazing results in the more time time period, but that does not issue. You shouldn't only want to operate around the issues of tomorrow, but also within the issues of the day soon after tomorrow.’

Our investigation ranges through the biophysics of DNA to artificial cells and over and above. Remember to take a look under on the spectrum of our recent assignments.

We use nanofabricated microfluidic structures to sample spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks which evaluate the basic position of spatial confinement with the molecular and cellular degree. Our tasks include things like the subsequent:

Instance (one) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in grey, the rim with the pore is highlighted in crimson, in addition to a 3D rendering on the movement in the DNA rod is shown.

This "Cited by" depend includes citations to the following content articles in Scholar. The ones marked * can be distinctive from the post inside the profile.

Resolving the action dimensions in condensin-pushed DNA loop extrusion ceesdekker.net identifies ATP binding as being the action-making course of action

FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial mobile division

2006, initial demonstration of molecular sorting in the lab with a chip utilizing biomotors; discovery of nanobubbles in reliable-point out nanopores; and first estimate of electrokinetic Vitality conversion in a very nanofluidic channel

2005, discovery with the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of very long-variety conformational improvements in Mre11/DNA restore complexes; and initially force measurements on the DNA molecule inside of a nanopore

It had been a very intriguing time, all through which I received a great deal of aid from Delft University of Engineering, wherever I was a professor at time, and I started off a number of collaborations with molecular biologists. That served me discover a good deal.’